Pankreas Kanser Hücresi

ABO blood group and risk of pancreatic cancer in a Turkish population in Western Blacksea region.

BACKGROUND: We aimed to investigate the relationship between blood groups andpancreatic cancer in a Turkish population in Western Blacksea region.
METHODS: This is a retrospective study. Zonguldak Karaelmas University outpatientoncology clinic records were screened for the period between 2004 and 2011.
RESULTS: The median age of patients were 56 (± 16) and 132 of 633 study population had pancreatic cancer. Pancreatic cancer patients had significantly higher rates of blood group A compared to controls (OR 1.8, 95%CI, p 0.005).
Rates of blood group AB was significantly lower than the control group (OR 0.37, 95% CI, p 0.04). The median survival (IR) time in subjects having the blood groups A, B, AB and O were 7.0 (1-28), 7.0 (2-38), 10 (2-36) and 9.0 (2-48) months respectively; the blood group 0 had significantly higher overall survival (OS) compared to the non-0 groups (p 0.04).
CONCLUSIONS: Pancreatic cancer patients had more common blood group A in our population. Moreover, blood group AB appeared to be a protective factor against pancreatic cancer in our population. Blood group 0 had a significantly longer survival compared to non-0, regardless of prognostic factors.